ODCs

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5 OMIM references -
5 associated genes
6 signs/symptoms

COMMON GENES: 1
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2

1 associated gene
4 signs/symptoms

Hereditary persistence of fetal hemoglobin - beta-thalassemia

Hemoglobin E - beta-thalassemia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	HBG2	(0.52)	HBB

Citations in the biomedical literature:

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Hemoglobin E - beta-thalassemia
	Synonym(s): - HPFH - beta-thalassemia		Synonym(s): - E-beta-thalassemia - HbE - beta-thalassemia

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare genetic disease - Rare hematologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: - Average age of death: - Type of inheritance: autosomal recessive

	External references: 5 OMIM references - No MeSH references		External references: No OMIM references No MeSH references


COMMON SIGNS	- Anaemia - Hemoglobinosis / hemoglobinopathy

Hereditary persistence of fetal hemoglobin - beta-thalassemia		Hemoglobin E - beta-thalassemia
	Very frequent - Pallor - Splenomegaly Frequent - Anomalies of bones / skeletal anomalies - Hepatomegaly / liver enlargement (excluding storage disease)		Very frequent - Immunodeficiency / increased susceptibility to infections / recurrent infections Frequent - Hyperferritinemia / iron overload